Treatment of Age Related Memory Impairment with Natural Products: A Review of Literature

Sarthak Bothra, Changda Liu, Xiaoke Chen, Xiu-Min

Background: Memory impairment is a natural occurrence that accompanies the aging process and is considered one of the most predominant outcomes of aging. However, it can lead to more serious impairments of cognitive function such as dementia. The aging of the global population has resulted in an increasing prevalence of dementia around the world. As a result, there has been an increase in interest to find novel approaches to alleviate cognitive impairment. Recently, there has been increased focus on the use of natural products for the treatment of memory impairment through the use of herbal medicine found in traditional medicines by slowing the aging related neurodegenerative process. Methods: In this study, data was gathered from the following search engines: PubMed, ScienceDirect, Google and ClinicalTrials.gov. When searching these databases, the following keywords were used to select studies: “memory impairment”, “cognitive’’, “herbal medicine”, “plant”, “inflammation”, and “oxidative stress”. All references used in this review article were written in English and the interval of time since publication did not exceed 20 years. References used in this review contain clinical, preclinical, in vivo, ex vivo, and in vitro studies with subjects including humans and numerous species of rats and mice. Results: After extensive research, 4 natural products Berberine, Ginseng, Ginkgo biloba, and BacopaMonnieri have shown significant success in studies to aging related cognitive impairment process. Treatment with these products appears to have desired effects on combating neurological disorders by interacting with the underlying mechanisms involved in the pathogenesis of many diseases. Conclusion and future directions: Further studies are required to further confirm the efficacy of herbal medicine in aged human patients afflicted with these neurological conditions.

 
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